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Improving estimates of children living with HIV from the Spectrum AIDS Impact Model

Journal Articles

By Mahy, Mary; Penazzato, Martina; Ciaranello, Andrea; Mofenson, Lynne; Yianoutsos, Constantin; Davies, Mary-Ann; Stover, John

Estimated numbers of children living with HIV determine programmatic and treatment needs. This paper explains the changes made to the UNAIDS estimates between 2015 and 2016 and describe the challenges around these estimates.

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Tenofovir Disoproxil Fumarate Safety for Women and their Infants During Pregnancy and Breastfeeding: Systematic Review

Journal Articles

By Mofenson, Baggaley, Mameletzis

Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data in pregnancy/lactation are limited.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

Journal Articles

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

Journal Articles

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Diagnosis of HIV Infection During Early Infancy: How Early Is Early Enough?

Journal Articles

By L. M. Mofenson

Diagnosis of HIV infection during early infancy (commonly known as “early infant HIV diagnosis” [EID]) is critical because HIV disease progression is much more rapid in children than adults, with mortality as high as 68% by age 2 years in infants with perinatal infection (acquired in utero or during the intrapartum period), with much of this risk occurring in the first few months of life. 

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Timing of initiation of antiretroviral therapy and adverse pregnancy outcomes: a systematic review and meta-analysis

Journal Articles

By Uthman, Nachega, Anderson, Kanters, Mills, Renaud, Essajee, Doherty, Mofenson

Although lifelong combination antiretroviral therapy (ART) is recommended for all individuals with HIV, few data exist for pregnancy outcomes associated with ART initiation before conception. This study assesses adverse pregnancy outcomes associated with ART initiated before conception compared with that of ART started after conception.

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From policy to action: how to operationalize the treatment for all agenda

Journal Articles

By Francesca Celletti, Jennifer Cohn, Catherine Connor, Stephen Lee, Anja Giphart and Julio Montaner

This article proposes the development and adoption of a differentiated care model as a practical approach to reach TfA and accelerate progress towards the 90–90–90 target.

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Opportunities and challenges in conducting secondary analysis of HIV programmes using data from routine health information systems and personal health information

Journal Articles

By Gloyd, Wagenaar, Woelk, Kalibala

Analyses focused on retrospective case reviews of four of the HIV-related studies published in this JIAS supplement. We identify specific opportunities and challenges with respect to the secondary analysis of RHIS and PHI data.

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Retention of mothers and infants in the prevention of mother-to-child transmission of HIV programme is associated with individual and facility-level factors in Rwanda

Journal Articles

By Woelk, Ndatimana, Behan, Mukaminega, Nyirabahizi, Hoffman, Mugwaneza, Ribakare, Amzel, Phelps

This study aims to investigate levels of retention at specified time periods along the prevention of mother-to-child transmission (PMTCT) cascade among mother-infant pairs as well as individual- and facility-level factors associated with retention.

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Lessons learned from the PMTCT program in Swaziland: challenges with accepting lifelong ART for pregnant and lactating women – a qualitative study

Journal Articles

By Katirayi, Chouraya, Kudiabor, Mahdi, Kieffer, Moland, Tylleskar

This study provides insight into the challenges of lifelong ART initiation among pregnant women under Option A in Swaziland.

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