Prevention of Mother-to-Child Transmission

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A case study on joint community-facility review of PMTCT dashboards in Malawi

Technical Briefs

This case study is intended for programme managers and others who are interested in strategies for involving communities in the review and use of health information to help women and children stay in care and improve prevention of mother-to-child transmission of HIV (PMTCT) programme performance and outcomes.

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Cluster-Randomized Controlled Study of SMS Text Messages for Prevention of Mother-to-Child Transmission of HIV in Rural Kenya

Journal Articles

By Kassaye, Ong’ech, Sirengo, Kose, Matu, McOdida, Simiyu, Syengo, Muthama, Machekano5

Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention.

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Tenofovir Disoproxil Fumarate Safety for Women and their Infants During Pregnancy and Breastfeeding: Systematic Review

Journal Articles

By Mofenson, Baggaley, Mameletzis

Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data in pregnancy/lactation are limited.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

Journal Articles

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

Journal Articles

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Timing of initiation of antiretroviral therapy and adverse pregnancy outcomes: a systematic review and meta-analysis

Journal Articles

By Uthman, Nachega, Anderson, Kanters, Mills, Renaud, Essajee, Doherty, Mofenson

Although lifelong combination antiretroviral therapy (ART) is recommended for all individuals with HIV, few data exist for pregnancy outcomes associated with ART initiation before conception. This study assesses adverse pregnancy outcomes associated with ART initiated before conception compared with that of ART started after conception.

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Retention of mothers and infants in the prevention of mother-to-child transmission of HIV programme is associated with individual and facility-level factors in Rwanda

Journal Articles

By Woelk, Ndatimana, Behan, Mukaminega, Nyirabahizi, Hoffman, Mugwaneza, Ribakare, Amzel, Phelps

This study aims to investigate levels of retention at specified time periods along the prevention of mother-to-child transmission (PMTCT) cascade among mother-infant pairs as well as individual- and facility-level factors associated with retention.

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Lessons learned from the PMTCT program in Swaziland: challenges with accepting lifelong ART for pregnant and lactating women – a qualitative study

Journal Articles

By Katirayi, Chouraya, Kudiabor, Mahdi, Kieffer, Moland, Tylleskar

This study provides insight into the challenges of lifelong ART initiation among pregnant women under Option A in Swaziland.

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Catalyzing Expanded Access to Early Testing, Care and Treatment for HIV-Exposed Infants

Fact Sheets

By late 2019, the four-year, U.S. $63 million UNITAID/Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) project aims to significantly increase the number of HIV-positive infants receiving life-saving treatment in nine project countries, and also develop robust global and national markets for affordable, effective and equitable HIV infant testing.

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Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

Journal Articles

Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with high CD4 counts are lacking.

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