Journal Articles

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Addressing Early Retention in Antenatal Care Among HIV-Positive Women Through a Simple Intervention in Kinshasa, DRC: The Elombe “Champion” Standard Operating Procedure

This cluster-randomized study measures the use of a standardized process (a standard operating procedure) to ensure consistency in retention support among HIV-positive women. It’s findings demonstrate a simple use of a procedure document has a positive effect on early retention of HIV-positive pregnant women on ART.

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Understanding Antiretroviral Treatment Adherence Among HIV-Positive Women at Four Postpartum Time Intervals: Qualitative Results from the Kabeho Study in Rwanda

This study explored attitudes and perceptions among a cohort of HIV-positive women in Rwanda about enrolment on lifelong antiretroviral treatment. This paper provides insight into the key times and reasons for decreased adherence in the 2 year postpartum period.

 

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Understanding the Role and Impact of Effective Country and Community Leadership in Progress Toward the Global Plan

By Lyons, Charles BA; Pillay, Yogan PhD

Individual leadership and leaders have played pivotal roles in the history of efforts to end the AIDS epidemic. The goal of this article is to reflect on and understand how leadership and leaders have impacted and enabled the success of the Global Plan Towards the Elimination of New HIV Infections among Children by 2015 and Keeping their Mothers Alive (Global Plan). To accomplish this goal, multiple interviews were conducted with individuals in positions of leadership who had been identified as people whose actions drove progress. Interviewees were selected from all levels of traditional hierarchies and sectors to provide a more complete account and representation of leadership, with a particular emphasis on the community, district, and country levels. The leaders interviewed provide insight into their work, motivations, and approaches to effective leadership. Through their experiences, they shed light on the strategies they used to drive changes in policy, programs, practice, and communities that allowed for progress toward the goals of the Global Plan. Leaders also identify future challenges and areas of improvement in the effort to end the AIDS epidemic that they feel require leadership and urgent action. In conclusion, this article identifies common characteristics of effective leadership and reflects on the experiences of individuals who are leaders in the effort to end the AIDS epidemic, and how their lessons learned can be applied to help realize future global...

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Detectable Viral Load in Late Pregnancy among Women in the Rwanda Option B+ PMTCT Program: Enrollment Results from the Kabeho Study

By Gill, Hoffman, Bobrow, Mugwaneza, Ndatimana, Ndayisaba, Baribwira, Guay, Asiimwe

This study explored the extent of viral suppression from a prevention of mother-to-child transmission of HIV program in Rwanda  among women enrolled in the Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV (Kabeho) Study.

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Cluster-Randomized Controlled Study of SMS Text Messages for Prevention of Mother-to-Child Transmission of HIV in Rural Kenya

By Kassaye, Ong’ech, Sirengo, Kose, Matu, McOdida, Simiyu, Syengo, Muthama, Machekano5

Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention.

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Improving estimates of children living with HIV from the Spectrum AIDS Impact Model

By Mahy, Mary; Penazzato, Martina; Ciaranello, Andrea; Mofenson, Lynne; Yianoutsos, Constantin; Davies, Mary-Ann; Stover, John

Estimated numbers of children living with HIV determine programmatic and treatment needs. This paper explains the changes made to the UNAIDS estimates between 2015 and 2016 and describe the challenges around these estimates.

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Tenofovir Disoproxil Fumarate Safety for Women and their Infants During Pregnancy and Breastfeeding: Systematic Review

By Mofenson, Baggaley, Mameletzis

Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data in pregnancy/lactation are limited.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Diagnosis of HIV Infection During Early Infancy: How Early Is Early Enough?

By L. M. Mofenson

Diagnosis of HIV infection during early infancy (commonly known as “early infant HIV diagnosis” [EID]) is critical because HIV disease progression is much more rapid in children than adults, with mortality as high as 68% by age 2 years in infants with perinatal infection (acquired in utero or during the intrapartum period), with much of this risk occurring in the first few months of life. 

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