Journal Articles | February 2019

Time to First-Line ART Failure and Time to Second-Line ART Switch in the IEDEA Pediatric Cohort

Manuscript published in the Journal of Acquired Immune Deficiency Syndromes
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Overview

Created by:

Kara Wools-Kaloustian, Irene Marete, Samuel Ayaya, et al. (EGPAF: Lynne Mofenson)

Topics:

Pediatric HIV Diagnosis, Care and Treatment; Strategic Information, Evaluation and Research

This article discusses the limited quantities of data concerning long-term durability of first-line ART regimens and time to transition to second-line among pediatric populations. Through a pediatric cohort study, this study team found that high rates of first-line failure and attrition were identified in children within 5 years after ART initiation. Of children meeting failure criteria, only one-third were transitioned to second-line ART within 5 years.