Time to First-Line ART Failure and Time to Second-Line ART Switch in the IEDEA Pediatric Cohort
Kara Wools-Kaloustian, Irene Marete, Samuel Ayaya, et al. (EGPAF: Lynne Mofenson)
Pediatric HIV Diagnosis, Care and Treatment; Strategic Information, Evaluation and Research
This article discusses the limited quantities of data concerning long-term durability of first-line ART regimens and time to transition to second-line among pediatric populations. Through a pediatric cohort study, this study team found that high rates of first-line failure and attrition were identified in children within 5 years after ART initiation. Of children meeting failure criteria, only one-third were transitioned to second-line ART within 5 years.