Journal Articles | February 2019

Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1 –Infected Women with High CD4 Cell Count (IMPAACT PROMISE): A randomized, Open-Label, Clinical Trial

Manuscript published in the Journal of Acquired Immune Deficiency Syndromes
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Overview

Created by:

Patricia M. Flynn, Tara E. Taha, May Cababasay, et al. (EGPAF: Lynne Mofenson)

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Strategic Information, Evaluation and Research

This randomized trial aimed to compare the efficacy of prolonged infant nevirapine (iNVP) prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child HIV transmission through breastfeeding cessation. After the randomized open-label trial concluded that both mART and iNVP prophylaxis strategies were safe and associated with very low breastfeeding HIV-1 transmission and high infant HIV-1-free survival at 24 months.