Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study
Nava Yeganeh, Tara Kerin, Bonnie Ank, et al. (EGPAF: Lynne Mofenson)
Prevention of Mother-to-Child Transmission; Strategic Information, Evaluation and Research
This study evaluated the prevalence and the effect of antiretroviral drug-associated resistance mutations (DRMs) in previously untreated mother-infant pairs. Through a case-control design, the research team evaluated DRMs as a predictor of mother-to-child HIV transmission (MTCT) in specimens obtained from mother-infant pairs. Results indicated that preexisting DRMs were common in untreated HIV-infected pregnant women, but did not increase the risk of HIV MTCT.