Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study

Overview

This study evaluated the prevalence and the effect of antiretroviral drug-associated resistance mutations (DRMs) in previously untreated mother-infant pairs. Through a case-control design, the research team evaluated DRMs as a predictor of mother-to-child HIV transmission (MTCT) in specimens obtained from mother-infant pairs. Results indicated that preexisting DRMs were common in untreated HIV-infected pregnant women, but did not increase the risk of HIV MTCT.