Compromise of Second-Line Antiretroviral Therapy Due to High Rates of Human Immunodeficiency Virus Drug Resistance in Mozambican Treatment-Experienced Children With Virologic Failure
Paula Vaz, W Chris Buck, Nilesh Bhatt, Dulce Bila, Andrew Auld, James Houston, Loide Cossa, Charity Alfredo, Kebba Jobarteh, Jennifer Sabatier, Eugénia Macassa, Amina Sousa, Josh DeVos, Ilesh Jani, Chunfu Yang
Affiliates; Pediatric HIV Diagnosis, Care and Treatment
Virologic failure (VF) is highly prevalent in sub-Saharan African children on antiretroviral therapy (ART) and is often associated with human immunodeficiency virus drug resistance (DR). Most children still lack access to routine viral load (VL) monitoring for early identification of treatment failure, with implications for the efficacy of second-line ART.