The Kabeho Study: Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV

About this study: In April 2012, the Government of Rwanda implemented a policy that would allow all HIV-positive women to be initiated on lifelong antiretroviral treatment (ART), known as Option B+. Rwanda also instituted an innovative infant feeding, counseling, and support program for HIV-positive women in the prevention of mother-to-child HIV transmission (PMTCT) programs. 

This study, known as Kabeho, takes advantage of a unique opportunity to both evaluate maternal and child outcomes in Rwanda Option B+ program.  The primary objective of this four-year study is to determine the 24-month HIV-free survival in a cohort of children born to approximately 600 HIV-positive pregnant women in 14 high volume antenatal clinics in Kigali, Rwanda, that are participating in the Rwanda National PMTCT program. Additional objectives include determining the individual- and facility-level factors associated with: 1) healthy infant nutritional outcomes (as defined by lack of stunting, underweight, or wasting) in the cohort of HIV-exposed children and 2) adherence to the Option B+ ART regimen among pregnant/postpartum women and their HIV-exposed children; and to document birth outcomes in the cohort of study infants exposed to triple drug ART regimens in utero.

The study utilizes a prospective observational cohort design and collects individual and facility data through a mixed methods approach with both quantitative and qualitative data. In addition, interviews with health care providers and PMTCT program leaders are conducted to assess implementation successes and challenges, and to gather recommendations for program improvement.

Status: This study is ongoing.

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Sub-study: Protocol Title: Antiretroviral Resistance Among Kabeho Study Women

About this sub-study: This study is a Dance Marathon at UCLA-funded analysis of existing laboratory samples from the Kabeho Study. The analysis aims to determine the presence of genotypic ARV resistance in a subset of HIV-infected infant and maternal samples.

Status: This study is ongoing.