Current Research Activities

Elizabeth Glaser was one of the first public figures to advocate for research focused on the prevention and treatment of HIV and AIDS in children. Since Elizabeth’s initial efforts, EGPAF has continued to bring together leading international scientists to conduct basic, clinical, and operations research as part of our global efforts to eliminate pediatric AIDS.

Over the last quarter century, the international research community has achieved great progress in deepening its scientific understanding of pediatric HIV and AIDS, leading to the development of innovations to address the epidemic among children. However, important challenges remain in ensuring access to and uptake of HIV testing, prevention, care and treatment services to all who need them.  EGPAF continues to lead the field in the conduct of clinical and implementation research to evaluate innovative strategies and novel technologies to contribute to this ever-growing body of knowledge.   EGPAF's research efforts specifically focus on determining the effectiveness of PMTCT and HIV care and treatment programs under real-world conditions, and assessing ways to increase the effectiveness of HIV-related health services and improve the health and wellbeing of women, children, and families. This includes developing effective and replicable comprehensive service delivery models that are well integrated within the health system with strong linkages to the communities that they serve.

Infant and Young Child Feeding

Safe infant and young child feeding practices offer an important opportunity to improve the HIV-free survival of future generations of HIV-exposed infants and keep HIV-infected children healthy. EGPAF is committed to evaluating and promoting safe and healthy infant and young child feeding practices.

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Prevention of Mother-to-Child Transmission and Implementation and Outcomes of the 2013 WHO Option B+ Guidelines

The elimination of pediatric HIV infection is a global priority in which considerable progress has been made, yet we remain far from achieving this goal. EGPAF continues to conduct research to understand and maximize the effectiveness of PMTCT programs. With the rapid evolution of WHO guidelines and the roll-out of the current simplified recommenda

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Pediatric Care and Treatment

The issues of timely access to diagnosis and treatment, adherence, retention in care, and advanced (second- and third-line) treatment for children and adolescents living with HIV must be prioritized in order to achieve and maintain viral suppression as well as prevent drug resistance.

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Community Approaches to Enhance HIV and AIDS Program Service Utilization

EGPAF has supported innovative models of community involvement to meet the needs of women, children, families, and communities affected by HIV. EGPAF assesses program and intervention effectiveness through operations research and impact evaluations, so successful community models can be replicated to assist in HIV prevention and treatment efforts.

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Integration of HIV Services With Other Routine Health Services

Integration of HIV prevention, care and treatment services with other health services (maternal and child health, family planning, TB etc.) is an important and practical strategy for strengthening health systems. EGPAF’s research in this area aims to evaluate integration models and inform scale-up of best practices.

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Maternal, Neonatal and Child Health

EGPAF takes a holistic approach to this area of health care; our efforts are focused on integrated efforts to improve health outcomes for all women, children and families. Our research in PMTCT and maternal, newborn and child health (MNCH) aims to contribute to the global body of MNCH knowledge and improve overall maternal and child survival.

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Long-Term Health Outcomes of Populations on ART

Ever-growing populations are living longer on antiretroviral therapy. Long-term retention in care and adherence to lifesaving ART are critical challenges to individuals and the health system. EGPAF is providing ongoing research on health risks and outcomes associated with ART across a lifetime.

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Health Care Workers: Knowledge, Skills and Attitudes

HIV and AIDS are concentrated in areas where health care human resource constraints exist. As programs expand to eliminate AIDS, the efforts will be squarely placed on overburdened staff. Our research in this area aims to contribute to knowledge around how to best use a limited number of staff to address the mission to end AIDS in children and prov

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